Misopess

The misoprostol vaginal insert (MVI) uses the same vaginal delivery system as the Cervidil® and Propess® inserts but with a different active ingredient, misoprostol. Misoprostol, a synthetic PGE1 analogue, is approved as a cytoprotective agent in combination with nonsteroidal anti-inflammatory drugs, but is frequently used “off-label” for cervical ripening.

Misoprostol has activity on both the cervix and the uterus and may serve both to ripen the cervix and augment labour. As such, the MVI may function as a one-step labour induction agent.