Pilobuc™

The Pilobuc™ insert is a modified release hydrogel polymer buccal insert containing pilocarpine. It has been developed for the treatment of symptoms associated with primary and secondary Sjögren's. The buccal insert is placed between the buccal mucosa and gingiva towards the back of the mouth.

The bio-adhesive hydrogel polymer swells in the presence of moisture, but does not dissolve. The active drug is released from the hydrogel polymer insert in a controlled manner for up to three hours, thus reducing frequent administration. The Pilobuc™ buccal insert gains maximum therapeutic effect without high peaks of drug release and the consequential side effect profile of pilocarpine oral tablets.

Currently available treatments are of short duration and can cause unpleasant side effects, including excessive sweating, nausea, flushing and urinary frequency. It is expected that Pilobuc’s sustained buccal delivery will reduce these side effects while providing longer relief of dry mouth symptoms.

Controlled Therapeutics have entered into an agreement with Marillion Pharmaceuticals to complete development and market this exciting product across the globe.